Anti-PNPO Antibody

Pyridoxal 5'-phosphate oxidase (PNPO) catalyzes the terminal activation step in vitamin B6 metabolism, converting pyridoxine 5'-phosphate into pyridoxal 5'-phosphate, the biologically active cofactor used across dozens of enzymatic reactions. Loss-of-function variants in PNPO are linked to pyridoxine-responsive neonatal epilepsy, making reliable detection tools important for ongoing metabolic research.

Produced by Antibodies.com, this unconjugated rabbit polyclonal IgG reagent specifically detects human PNPO in western blot applications. The polyclonal format recognizes multiple epitopes on the target protein, supporting reproducible band patterns across denaturing lysate preparations from human cell lines and tissues.

Shipped as a 200 µl volume in a vial, the antibody can support multiple western blot runs. Store frozen at -20 °C in small aliquots and limit freeze-thaw cycles to preserve binding activity. For research use only; not validated or intended for diagnostic applications.