Anti-PNP Antibody

This polyclonal primary antibody from Antibodies.com targets purine nucleoside phosphorylase (PNP), a key enzyme in the purine salvage pathway that catalyzes the reversible phosphorolysis of purine ribonucleosides to free bases and ribose-1-phosphate. Raised in rabbit, the unconjugated reagent is supplied as 100 µl of liquid and is validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples.

Because PNP deficiency is associated with severe combined immunodeficiency, dependable detection of the enzyme supports research on lymphoid differentiation and purine metabolism, while tissue expression patterns are commonly examined by IHC in hematopathology and oncology studies. The polyclonal format enables recognition of multiple epitopes on the target, which can be useful when working with tissues where single-clone antibodies may give weaker signals. The reagent is supplied in a vial format, ready to aliquot for storage at -20 °C in working volumes, and can be diluted further into appropriate buffers for downstream immunostaining or immunoblotting applications.