Anti-PNOC Antibody

This polyclonal reagent from Antibodies.com is raised in rabbit against human prepronociceptin (PNOC), the precursor polypeptide that gives rise to nociceptin/orphanin FQ (N/OFQ), a 17-amino-acid opioid-like neuropeptide involved in pain modulation, stress responses, anxiety, and reward circuitry. The unconjugated IgG fraction is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial format suitable for repeated immunodetection experiments.

Validated application areas include Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) on human samples, where the antibody recognizes endogenous PNOC protein in tissue sections and cell preparations. Researchers studying GPCR signaling through the NOP receptor (also known as ORL1), neuropeptide processing pathways, or comparative opioid-receptor pharmacology use this reagent as a tool for mapping prepronociceptin expression across nervous-system tissue. Storage at -20 °C in working aliquots is recommended to limit freeze-thaw cycles of the glycerol-containing formulation, with the sodium azide acting as a microbial preservative for routine benchtop handling.