Anti-PNMT Antibody

Raised in rabbit against phenylethanolamine N-methyltransferase, this polyclonal primary antibody from Antibodies.com targets the terminal enzyme of catecholamine biosynthesis—the step that converts norepinephrine to epinephrine. Supplied as 100 µl of unconjugated antiserum, it supports Western blot and immunohistochemistry workflows and has been validated for reactivity with human, mouse, and rat samples.

PNMT is concentrated in chromaffin cells of the adrenal medulla and in select adrenergic neuron populations of the central nervous system, so the antibody helps map sympathoadrenal tissue architecture, characterize epinephrine-producing cell populations, and track enzyme regulation in models of stress, glucocorticoid signaling, hypoxia, or neurodegeneration. Its polyclonal nature gives broader epitope coverage than monoclonal alternatives, increasing the chance of clean detection across species and across PNMT variants.

The unconjugated format keeps the workflow flexible: pair the reagent with a horseradish peroxidase secondary for chromogenic IHC, a fluorescent secondary for multiplex imaging, or an enhanced chemiluminescence system for Western blot. Store refrigerated and minimize freeze-thaw cycles between aliquots to preserve titer across many experiments.