Anti-PML Protein Antibody

Raised in rabbit against the human PML (Promyelocytic Leukemia) nuclear body organizer, this unconjugated polyclonal IgG reagent from Antibodies.com targets a protein best known for scaffolding PML nuclear bodies (PML-NBs) and for its role in the t(15;17) PML-RARα fusion characteristic of acute promyelocytic leukemia. The 100 µg lyophilised preparation is supplied as a research-grade primary antibody validated for Western blot and immunofluorescence workflows on human samples, where it labels the characteristic speckled nuclear pattern produced by PML-NBs and supports studies of SUMO-dependent nuclear body assembly, DNA damage response signaling, and interferon-driven antiviral defense pathways. Reconstitute in sterile buffer before use; keep refrigerated, protect from light, and avoid repeated freeze-thaw cycles to preserve reactivity across multiple experiments.