Anti-PML Antibody

PML (Promyelocytic Leukemia protein) is the defining scaffold of PML nuclear bodies, dynamic subnuclear compartments that orchestrate DNA damage repair, intrinsic antiviral defenses, and SUMO-dependent transcriptional control. This unconjugated rabbit polyclonal reagent from Antibodies.com detects endogenous PML across human and murine samples in western blot, immunohistochemistry, and immunofluorescence workflows, supporting studies of oncogenic transformation, viral restriction pathways, and PML-RARα fusion biology in acute promyelocytic leukemia research.

Supplied as a 100 µl aliquot at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% glycerol, the antibody dilutes readily into standard blocking buffers for both fixed-cell imaging and denatured lysate blotting. The polyclonal format provides broader recognition of the multiple PML isoforms that arise from alternative splicing of the PML gene, which is valuable when characterizing nuclear body reorganization following genotoxic stress or viral infection in cell culture and tissue sections.