Anti-PLXNA4 Antibody

This rabbit polyclonal antibody from Antibodies.com targets PLXNA4, the gene encoding Plexin-A4, a transmembrane semaphorin receptor best known for its role in axon guidance and semaphorin signalling during nervous system development. Plexin-A4 has also attracted attention in immune and cancer research because it modulates dendritic cell migration and has been reported to influence response to immune checkpoint blockade in preclinical tumour models, making anti-PLXNA4 tools useful across both neuroscience and immuno-oncology workflows.

The reagent is supplied at 1 mg/ml in phosphate buffered saline with 15 mM sodium azide at approximately pH 7.2, and ships as a 100 µl vial of unconjugated antiserum suitable for western blot detection in mouse and rat samples. Store refrigerated at 2 to 8 degrees C; protect from light, and avoid freeze-thaw cycles to preserve activity. The polyclonal format increases the likelihood of recognising multiple epitopes on Plexin-A4, which is useful when probing full-length receptor expression in tissue lysates.

Researchers commonly apply this reagent to confirm expression of PLXNA4 across brain regions and to investigate changes in Plexin-A4 abundance under experimental manipulation of semaphorin signalling pathways. Because the host species is rabbit, anti-rabbit secondary antibodies should be selected for downstream chemiluminescent or chromogenic detection on western blot membranes.