Anti-PLK1 Antibody

Raised in rabbit, this polyclonal antibody from Antibodies.com targets PLK1 (Polo-like Kinase 1), a conserved serine/threonine kinase that drives mitotic entry and cytokinesis. The unconjugated reagent is supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, and is validated for Western blot, immunohistochemistry, and immunofluorescence on human, mouse, and rat samples.

PLK1 activity peaks at the G2/M transition and governs centrosome maturation, bipolar spindle assembly, kinetochore signaling, and the spindle assembly checkpoint. Because PLK1 is frequently overexpressed in proliferating tumor cells, this antibody is widely used in cell cycle research, mitotic studies, and oncology signal-transduction work. The polyclonal format provides multi-epitope recognition, supporting detection of PLK1 in whole-cell lysates, cultured cells, and fixed tissue sections. Store the vial at -20 °C in working aliquots, protect from light, and limit freeze-thaw cycles. For research use only.