Anti-PLEKHO1 Antibody

Raised in rabbit against human PLEKHO1, this polyclonal antibody from Antibodies.com targets a pleckstrin homology domain-containing adapter that couples casein kinase 2 activity to cytoskeletal remodeling and to negative feedback on the PI3K/Akt pathway. The unconjugated reagent is supplied as 100 µl of ready-to-use antiserum and is validated for immunoblotting (WB) and immunohistochemistry (IHC) on human and mouse samples, supporting studies of bone homeostasis, myogenic differentiation, and receptor signaling where CKIP-1 (the common alias) has been implicated.

The immunogen lies in a conserved region of the protein, so the reagent detects the native antigen in denatured lysates by western blot and produces cytoplasmic and membrane-associated staining patterns in fixed tissue sections, making it useful as a primary detection reagent for tracking endogenous expression across cell lines and animal models. Aliquot upon first thaw to minimize freeze-thaw cycles, and store refrigerated short term or frozen in single-use portions for longer term.