Anti-PLCG2 (phospho Y1217) Antibody

Phospholipase C gamma 2 (PLCG2) is an intracellular signaling enzyme critical to B-cell receptor cascades and other immune pathways, where its activation drives inositol trisphosphate production and downstream calcium mobilization. Antibodies.com offers this affinity-purified rabbit polyclonal antibody raised against a phosphorylated peptide flanking tyrosine 1217 of human PLCG2, enabling selective detection of the activated, phospho-Y1217 form of the enzyme in fixed tissue sections. Provided as a 50 µl liquid aliquot of polyclonal IgG, unconjugated and affinity-purified, and validated for immunohistochemistry on human, mouse, and rat samples. Researchers use this reagent to monitor pathway activation in B-cell lymphoma models, mast cell degranulation studies, and microglia or macrophage signaling investigations. For best results, store frozen at -20°C and aliquot to limit freeze-thaw cycles of the polyclonal stock.