Anti-PLCG2 (phospho Y1217) Antibody

This phospho-specific rabbit polyclonal antibody targets phospholipase C gamma 2 at tyrosine 1217, the activating phosphorylation site generated downstream of B-cell receptor and Fc receptor engagement. By binding only when PLCG2 carries this phosphate, the reagent resolves the catalytically engaged pool from the total enzyme pool in tissue sections, a distinction useful in studies of B-cell signaling, germinal center biology, and lymphoid malignancies where pathway activation status is the variable of interest.

Validated for immunohistochemistry on formalin-fixed, paraffin-embedded material, the unconjugated IgG reagent from Antibodies.com is supplied as 100 µl and reacts with human, mouse, and rat PLCG2. Researchers working on lymphoma models, autoinflammatory signaling, or downstream effector pathways can pair this phospho-specific antibody with total PLCG2 reagents to monitor Y1217 activation status in situ across cross-species lymphoid compartments such as spleen, lymph node, and tonsil. Handle under cold-chain conditions to preserve phospho-epitope recognition; intended for research use only.