Anti-PLCG2 Antibody

PLCG2 (phospholipase C gamma 2) is a cytoplasmic signaling enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG), driving calcium mobilization and protein kinase C activation downstream of B-cell receptor, Fc receptor, and receptor tyrosine kinase pathways. Mutations in PLCG2 are linked to immune dysregulation syndromes, including PLAID and APLAID, and the enzyme is widely studied in B-cell lymphoma biology and chronic lymphocytic leukemia signaling.

This rabbit polyclonal antibody from Antibodies.com targets PLCG2 and is validated for western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) workflows across human, mouse, and rat samples. The unconjugated polyclonal reagent is supplied as 100 µl, supporting flexible experimental design that ranges from endogenous co-immunoprecipitation and pull-down assays in lymphoid cell lines to fixed-tissue immunofluorescence imaging of hematopoietic and immune cell populations. Cross-reactivity data are summarized as reactive with Human, Mouse, and Rat, with the unconjugated format allowing researchers to pair the antibody with secondary detection reagents of their choice.