Anti-PLC γ2 (phospho-Y753) Antibody

Phospholipase C β2 (PLC β2) is a key enzyme in phosphoinositide hydrolysis and intracellular calcium signaling. Tyrosine 753 phosphorylation of PLC β2 is associated with signaling downstream of receptor tyrosine kinases and immune cell receptors, including the B-cell receptor pathway. This affinity-purified rabbit polyclonal reagent from Antibodies.com recognizes PLC β2 only when phosphorylated at Y753, supporting studies of kinase-dependent regulation in hematopoietic and immune cell contexts.

Provided at 1 mg/mL in PBS (pH ~7.2) containing 0.05% sodium azide, the unconjugated antibody is supplied as a 100 µL aliquot and is validated for Western blot and immunohistochemistry. Cross-reactivity with mouse and rat orthologs extends the reagent to comparative studies alongside human samples. The polyclonal format delivers recognition of multiple epitopes surrounding phospho-Y753, useful when probing native lysates or fixed tissue sections where single-clone coverage can be limiting. Researchers commonly aliquot the antibody on first use to limit repeated freeze-thaw cycles of the stock solution.