Anti-PKMYT1 Antibody

Targets the membrane-associated tyrosine/threonine kinase PKMYT1, a key regulator of the G2/M cell cycle transition that phosphorylates and inhibits CDK1 to delay mitotic entry under DNA damage conditions. This polyclonal reagent from Antibodies.com is raised in rabbit and supplied as 100 µl of unconjugated antibody, ready for incorporation into standard western blot and immunohistochemistry workflows on human and mouse tissue specimens.

PKMYT1 has emerged as a focus in oncology and cell cycle biology research, where altered expression or activity is associated with tumor proliferation, checkpoint fidelity, and responses to genotoxic stress. Investigators studying mitotic entry, DNA damage response pathways, or therapeutic sensitization strategies can apply this antibody to interrogate endogenous PKMYT1 levels across cultured cell lines, xenograft models, and primary tissue sections, with cross-reactivity confirmed for both human and murine samples.

Storage at -20 °C in working aliquots preserves antibody activity across repeated freeze-thaw cycles, supporting reproducible band patterns on western blot and clean chromogenic or fluorescent signals in IHC. Each lot is quality-validated by Antibodies.com for species reactivity, reducing the need for separate reagents when moving between human cell-based assays and mouse model systems.