Anti-PKM2 Antibody

PKM2 (Pyruvate Kinase M2) is a critical glycolytic enzyme that catalyzes the final rate-limiting step of glycolysis, converting phosphoenolpyruvate to pyruvate while generating ATP. Beyond its canonical metabolic role, PKM2 is widely studied in cancer biology because of its central involvement in the Warburg effect, where tumor cells favor aerobic glycolysis over oxidative phosphorylation.

This unconjugated, rabbit polyclonal antibody from Antibodies.com targets human PKM2 and is supplied as 100 µl of reagent, validated for Western blot, immunohistochemistry, and immunofluorescence workflows in research use only studies.

The reagent supports investigation of tumor metabolism, regulation of glycolysis in proliferating cells, and the non-metabolic nuclear functions of PKM2, including its documented role as a transcriptional co-activator and protein kinase. Validated on human samples, it aids studies of cancer cell signaling, metabolic reprogramming, and the dimer-to-tetramer transition of PKM2 that influences both its enzymatic activity and its subcellular localization between cytoplasm and nucleus.

For handling, the antibody should be refrigerated upon receipt, aliquoted to limit freeze-thaw cycles, and stored to preserve activity across its shelf life. Each vial of this polyclonal reagent is intended for laboratory research applications probing glycolytic control, oncogenic signaling pathways, and the contribution of PKM2 to disease states such as cancer and inflammatory disorders.