Anti-PKM1 Antibody

Pyruvate kinase M1 (PKM1) is the constitutively active isoform of the glycolytic enzyme pyruvate kinase, expressed predominantly in terminally differentiated tissues such as skeletal muscle and brain, where it catalyses the final step of glycolysis and supports high-rate ATP generation. This rabbit polyclonal reagent from Antibodies.com is raised against PKM1 and validated for Western blot and immunofluorescence detection on human and mouse samples.

Supplied as an unconjugated antiserum in a 100 µl volume, the antibody enables discrimination of PKM1 from the alternatively spliced PKM2 isoform, which is broadly expressed in embryonic tissue and frequently reactivated in proliferating and tumor cells. Researchers investigating metabolic reprogramming, isoform-specific gene regulation, or tissue distribution of pyruvate kinase can apply the reagent to routine Western blot workflows and IF imaging of fixed cells and tissue sections. Intended for research use only.