Anti-PKLR Antibody

Raised in rabbit, this unconjugated polyclonal IgG antibody from Antibodies.com targets the pyruvate kinase L/R enzyme encoded by the PKLR gene, a key glycolytic regulator responsible for catalyzing the final step of glycolysis by transferring a phosphate group from phosphoenolpyruvate to ADP. The reagent is supplied as a 200 µL vial of ready-to-use liquid and has been validated for Western blot and immunohistochemistry applications on human samples, making it useful for studies of red blood cell metabolism, hepatocyte biochemistry, and the molecular basis of hereditary non-spherocytic hemolytic anemia linked to PKLR deficiency. Its polyclonal nature allows recognition of multiple epitopes on both the PKL (liver) and PKR (erythroid) isoforms, which is helpful when probing tissue-specific expression patterns or characterizing loss-of-function variants in patient-derived material. The unconjugated format gives researchers flexibility to pair the antibody with their own secondary detection reagents and fluorophore or enzyme choices, and the IgG isotype is compatible with standard chromogenic and fluorescence workflows used in clinical and translational research settings.