Anti-PKC ζ Antibody

A rabbit polyclonal immunoglobulin raised against Protein Kinase C zeta (PKC ζ), an atypical serine/threonine kinase that operates independently of calcium and diacylglycerol. Provided by Antibodies.com as an unconjugated primary reagent in a 100 µl volume, this antibody supports western blot, immunohistochemistry, immunofluorescence, and ELISA workflows across human, mouse, rat, and monkey samples.

PKC ζ contributes to NF-κB signalling, establishment of cell polarity, insulin response, and neuronal development, making this reagent useful for studies of inflammation, glucose homeostasis, and tissue organisation. On SDS-PAGE the target migrates near 80 kDa, a useful reference for confirming band identity in lysates from cell lines, primary cultures, and tissue biopsies. Researchers commonly apply it to hippocampal and cortical sections for IHC mapping of atypical PKC expression and to paraffin-embedded tumour biopsies where PKC ζ supports proliferative and survival signalling.

Because the antibody is unconjugated, it can be paired with HRP-, biotin-, or fluorophore-labelled secondary reagents chosen to match the detection platform. Aliquot on first use and store refrigerated to preserve polyclonal titre across long-term studies. The polyclonal format offers recognition of multiple epitopes on PKC ζ, an advantage when working with post-translationally modified or alternatively spliced variants of the kinase.