Anti-PKAα/β cat (V191) Antibody

This rabbit polyclonal antibody from Antibodies.com targets the catalytic subunit of cAMP-dependent protein kinase (PKA), recognizing both the PKAα and PKAβ isoforms at the conserved V191 epitope region. Produced in rabbit and supplied at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, the unconjugated reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

The 50 µl format suits multi-application projects probing cAMP/PKA signaling cascades, including studies of synaptic plasticity, GPCR-coupled signaling, CREB phosphorylation, and downstream transcriptional regulation. Researchers investigating neuronal memory, cardiac contractility, metabolic regulation, and tumor-associated kinase signaling commonly use this reagent to track catalytic subunit expression, localization, and activation state in fixed and lysed preparations.

Polyclonal reactivity broadens epitope coverage within the catalytic subunit, supporting detection of full-length PKA as well as processed or partially degraded species under denaturing western blot conditions. Aliquot upon first use to limit freeze-thaw cycles and store refrigerated at 4°C for short-term handling or frozen for longer-term stability.