Anti-PKAα/β cat (phospho-T197) Antibody

This rabbit polyclonal reagent from Antibodies.com targets the phosphorylated activation-loop residue threonine 197 of cAMP-dependent protein kinase catalytic subunits alpha and beta, a site whose modification is required for full enzymatic activity. The unconjugated antibody is supplied at 1 mg/ml in phosphate buffered saline (pH 7.2) with 15 mM sodium azide as preservative, packaged as a 100 µl aliquot. Validated applications include Western blot for monitoring phosphorylation state across cell and tissue lysates, and immunohistochemistry for localization studies on fixed sections. Reactivity has been confirmed in human, mouse, and rat samples, supporting cross-species research in signalling, neuroscience, metabolic, and cancer pathways where PKA activity is a read-out of cAMP signalling. The polyclonal format provides broader epitope coverage around the phospho-T197 site, useful when probing conformational context or compensatory subunit usage in cell-based and tissue-based assays.