Anti-PIWIL4 Antibody - Identical to Abcam (ab180867)

A rabbit polyclonal IgG reagent raised against the PIWI-clade Argonaute protein PIWIL4, also referred to as HIWI2 in humans and Miwi2 in mouse, is offered by Antibodies.com as an unconjugated primary antibody in a 50 µl volume. PIWIL4 operates in the nucleus of foetal gonocytes, where it partners with PIWI-interacting RNAs (piRNAs) to direct de novo DNA methylation of young LINE1 and IAP retrotransposon copies during male germline development, an activity that requires cooperating factors such as SPOCD1 and TEX15. The reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows and detects the endogenous protein across human, mouse, and rat samples, supporting studies of spermatogenesis, transposon repression, and emerging applications in cancer biology and stem cell maintenance. Upon arrival, aliquot the antibody and store frozen at -20 °C, protecting it from repeated freeze-thaw cycles to preserve binding activity over long-term use in research use only settings.