Anti-PIWIL3 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets the PIWIL3 protein, a member of the Argonaute/PIWI family implicated in piRNA-mediated transposon silencing and germline gene regulation. The reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit, validated for western blot and immunohistochemistry workflows against human and mouse samples.

PIWIL3 (also called HIWI3) is one of four human PIWI paralogues and is expressed predominantly in the testis, with roles in spermatogonial stem cell maintenance and retrotransposon repression during gametogenesis. The antibody is therefore a useful research reagent for studies of male germline biology, reproductive epigenetics, and the broader piRNA pathway, and has also been applied in investigations of PIWI-family expression in certain tumor types.

As a polyclonal, the reagent recognizes multiple epitopes across the PIWIL3 sequence, which can help when working with samples where target abundance is low or where minor isoform differences matter. It is provided unconjugated, allowing end users to couple it to fluorophores, biotin, or enzymes depending on their western blot or immunohistochemistry detection chemistry. Store refrigerated and protect from repeated freeze-thaw cycles to preserve antibody activity.