Anti-PIWIL2 Antibody

The PIWIL2-targeted polyclonal preparation supplied by Antibodies.com is a rabbit-derived, unconjugated reagent provided as a 50 µl aliquot, validated for western blot and immunohistochemistry workflows on human samples.

PIWIL2 (also known as HILI in human cells) is a member of the Piwi subfamily of Argonaute proteins, contributing to piRNA-guided silencing during germline development and to piRNA-independent regulatory roles reported in somatic and cancer-cell contexts. A rabbit polyclonal format recognizes multiple epitopes across the target, supporting comparative expression studies that probe transposon-silencing pathways and germ-cell marker panels in tissue and lysate preparations. The reagent is suited to investigations in spermatogenesis, stem-cell biology, and tumour biology where PIWIL2 status is being mapped against disease or differentiation states.

With reactivity restricted to human specimens, the reagent delivers consistent results across matched-pair studies of normal and tumour tissue, while the unconjugated format allows pairing with user-selected secondary reagents for chromogenic or fluorescence detection, preserving flexibility across routine and exploratory assays. For western blot, expected band behaviour should be confirmed against the target's predicted molecular weight, and immunohistochemistry optimisation on control sections is recommended before deploying the antibody on novel tissue cohorts.