Anti-PIP5K3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets PIP5K3, the phosphatidylinositol 4-phosphate 5-kinase type III also known as PIKfyve, a large endosome-associated lipid kinase of roughly 237 kDa that generates PI(3,5)P2 and supports vacuolar and endosomal membrane trafficking, retroviral budding, and insulin-stimulated GLUT4 translocation in mammalian cells.

Supplied as 100 µl of polyclonal antiserum at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated IgG fraction is validated for western blot and immunohistochemistry on human and mouse samples, with empirical titration recommended for each application.

Mutations in the PIP5K3/PIKFYVE gene are linked to François-Neetens fleck corneal dystrophy, and the kinase has been implicated in endolysosomal signaling and autophagy-related research, making this reagent useful for laboratories investigating phosphoinositide metabolism, endosome maturation, and related vesicular trafficking pathways. Store the vial refrigerated; the 50% glycerol cryoprotectant permits storage at -20 °C for extended periods without freeze-thaw damage. Protect from light and minimize repeated freeze-thaw cycles to preserve antibody activity.