Anti-PIP5K1A Antibody

The antibody targets phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5K1A), a lipid kinase that catalyzes phosphorylation of phosphatidylinositol 4-phosphate at the D5 position of the inositol ring to generate phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 is a key substrate for phospholipase C and phosphoinositide 3-kinase signaling pathways, and it regulates actin cytoskeleton dynamics at focal adhesions, synaptic vesicle trafficking in neurons, and receptor-mediated cell signaling.

The unconjugated rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl in a vial and is validated for Western blot and immunohistochemistry on human samples. Polyclonal preparations recognize multiple epitopes across the target, which can be useful when probing proteins with variable post-translational modifications or splice isoforms. Researchers using this reagent often work in cell signaling, membrane biology, or oncology-focused projects where PIP5K1A expression, localization, or activity is being characterized.