Anti-PIK3R2 Antibody [Assigned #A11086]

Raised in rabbit and supplied as 100 µl of ready-to-use, unconjugated IgG reagent, this monoclonal antibody from Antibodies.com targets the p85β regulatory subunit encoded by PIK3R2, a core component of class I phosphoinositide 3-kinase. Validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows, the reagent detects endogenous p85β in human and rat samples and is calibrated for reproducible batch-to-batch performance across cell culture lysates, primary neuronal preparations, and formalin-fixed paraffin-embedded tissue sections.

The PI3K/AKT signaling cascade governs cell growth, survival, and metabolic response, and PIK3R2 dysfunction has been linked to insulin resistance, glioblastoma progression, and the developmental overgrowth disorder MPPH (megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome). Investigators working with tumor cell lines, brain tissue, or metabolic signaling models can deploy this reagent to monitor p85β expression and its modulation by upstream kinases. The unconjugated format allows flexible pairing with custom fluorophore or enzyme labels, and the rabbit host is fully compatible with standard anti-rabbit IgG secondary antibodies used in chromogenic and fluorescence detection. Store refrigerated at 4 °C for short-term use or freeze at -20 °C for long-term stability, aliquoting upon first use to avoid repeated freeze-thaw cycles and preserve binding activity. For research use only.