Anti-PIAS2 Antibody

Produced in rabbit and supplied as an unconjugated polyclonal preparation, this Antibodies.com primary antibody targets PIAS2 (Protein Inhibitor of Activated STAT2), a SUMO E3 ligase that catalyzes conjugation of SUMO to substrate proteins. Validated for western blot, immunohistochemistry, and immunofluorescence, the reagent reacts with human, mouse, and rat samples, supporting cross-species comparative work.

PIAS2 modulates JAK-STAT signaling through STAT2 binding, participates in SUMO-dependent transcriptional regulation, contributes to chromatin remodeling, and operates within the DNA damage response. These roles make the antibody relevant to studies of innate immunity, nuclear receptor activity, and post-translational modification biology. Researchers tracking PIASx-alpha and PIASx-beta isoform distribution in cultured cells, primary isolates, and fixed tissue sections incorporate the reagent into standard immunolabeling workflows with dilution optimization per application.

Supplied as a 100 µl liquid aliquot, the antibody is intended for research use only. Refrigerated storage between uses is recommended, with aliquoting advised to limit freeze-thaw cycles and preserve binding activity over the working shelf life.