Anti-PIAS 3 Antibody

Rabbit polyclonal antisera raised against PIAS 3, the SUMO E3 ligase that negatively regulates STAT3-mediated transcription. Produced by Antibodies.com as an unconjugated reagent validated for Western blot, immunohistochemistry, and ELISA across human, mouse, and rat samples.

The 100 µL volume is supplied in a vial format that allows flexible pairing with secondary antibodies for chromogenic, fluorescent, or chemiluminescent detection workflows. PIAS 3 modulates cytokine signaling through inhibition of activated STAT3, with documented roles in inflammatory responses, oncogenic signaling pathways, and regulation of cellular differentiation.

As a polyclonal reagent, the antibody recognizes multiple epitopes on the target, improving tolerance for minor sequence variation between species. The reagent is compatible with standard immunoblotting membranes, formalin-fixed paraffin-embedded tissue sections, and standard microplate ELISA workflows.