Anti-PI 3-kinase p85α / γ Antibody

Manufactured by Antibodies.com, this unconjugated polyclonal reagent is raised in rabbit and supplied in a 100 µl volume. It targets the regulatory subunit of class I PI 3-kinase, with reactivity reported toward both p85α and p85γ isoforms, making it a practical tool for kinase signaling research and pathway dissection studies.

PI 3-kinase occupies a central node in intracellular signaling networks that govern cell growth, proliferation, survival, glucose homeostasis, and immune cell function. The p85 family of regulatory subunits recruits the catalytic p110 subunit to activated receptor tyrosine kinases at the plasma membrane, so tracking p85α expression provides a useful readout for PI3K pathway engagement in cancer biology, insulin response research, and studies of receptor-driven mitogenic signaling in hematopoietic and epithelial systems.

Validation covers Western blot detection of protein expression, immunofluorescence imaging for subcellular localization, immunohistochemistry on formalin-fixed tissue sections, and ELISA-based quantification workflows. Demonstrated cross-reactivity includes human, mouse, rat, and monkey samples, enabling translational pipelines that move between rodent disease models and primate or human tissue validation.