Anti-PHYH Antibody

Phytanoyl-CoA hydroxylase (PHYH) carries out the initial alpha-oxidation step of branched-chain fatty acid catabolism inside peroxisomes, and Antibodies.com offers a polyclonal IgG reagent raised in rabbit against this enzyme for Western blot and immunofluorescence work. The unconjugated format keeps the antibody flexible for downstream labeling, while reactivity to both human and mouse samples broadens the range of cell and tissue models it can address.

PHYH loss-of-function variants underlie adult Refsum disease and broader peroxisomal biogenesis disorders, so reliable detection matters for studies of fatty acid metabolism, organelle integrity, and metabolic disease mechanisms. Researchers typically apply this reagent to confirm expression in hepatic or neural cell systems, to validate CRISPR-edited knockout lines, or to compare patient-derived fibroblasts against healthy donor controls.

The polyclonal format provides broader epitope coverage than a monoclonal, useful when probing a low-abundance target with limited mapped epitopes. Each 50 uL vial is supplied ready for aliquoting on arrival; refrigerate between uses to limit freeze-thaw damage and preserve titer for repeated experiments.