Anti-Phosphodiesterase 9A Antibody

Raised in rabbit against human Phosphodiesterase 9A (PDE9A), this polyclonal antiserum from Antibodies.com is supplied as 100 µl of unconjugated reagent and is suited to western blot and immunohistochemistry workflows. PDE9A is the high-affinity, cGMP-selective member of the mammalian phosphodiesterase family, distinguished by tandem GAF regulatory domains and broad tissue distribution that includes brain, kidney, and spleen. The enzyme is encoded on chromosome 21q22.3, a region linked to Down syndrome phenotypes, and has become a focus of medicinal chemistry efforts targeting central nervous system indications.

The reagent supports detection of endogenous PDE9A in human tissue sections and cell lysates, enabling studies of cyclic GMP hydrolysis, neuronal and renal expression patterns, and selective inhibitor screening in cell-based or biochemical assays. Researchers can apply it to characterize PDE9A distribution across normal and disease-associated tissues, monitor pathway modulation following pharmacological intervention, and benchmark results against published selective tool compounds such as BAY 73-6691 and related chemotypes.

Validation is reported for human samples, with western blot and immunohistochemistry serving as the primary readouts. The unconjugated format allows flexible pairing with secondary detection reagents of the researcher's choice, supporting both chromogenic and fluorescence-based visualization strategies in established laboratory protocols.