Anti-Phosphatidylcholine-sterol acyltransferase Antibody

A rabbit polyclonal reagent from Antibodies.com, this unconjugated primary antibody targets phosphatidylcholine-sterol acyltransferase (LCAT), the plasma enzyme that esterifies cholesterol on HDL particles during reverse cholesterol transport. Supplied at 100 µg, it is validated for Western blot and immunohistochemistry on human samples.

Because LCAT loss-of-function variants cause familial LCAT deficiency and fish-eye disease, the antibody is widely applied in cardiovascular and lipid-metabolism studies. Researchers use it to probe enzyme expression in patient-derived samples, hepatocyte models, and macrophage cultures, mapping patterns relevant to HDL maturation, atherogenesis, and cholesterol homeostasis.

Polyclonal recognition of multiple epitopes on the target supports robust IHC staining of tissue sections and consistent band detection on Western blot membranes. Aliquoting the reagent upon receipt and limiting freeze-thaw cycles preserves long-term binding activity across repeated experimental runs.