Anti-PHLDA3 Antibody [4B6]

The Anti-PHLDA3 Antibody [4B6] from Antibodies.com is a mouse monoclonal reagent of the IgG2b isotype, supplied as a liquid formulation at 100 µg. PHLDA3 (Pleckstrin Homology Like Domain Family A Member 3) is a p53-responsive gene encoding a pleckstrin homology domain protein that acts as a tumor suppressor by inhibiting Akt signaling through competition for phosphatidylinositol (3,4,5)-trisphosphate binding. This unconjugated antibody is validated for western blot detection of human PHLDA3, enabling study of its expression in cell lysates and tumor samples. For handling, aliquot the antibody upon arrival and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve binding activity.