Anti-PGRMC2 Antibody

PGRMC2 (Progesterone Receptor Membrane Component 2) belongs to the membrane-associated progesterone receptor family and participates in steroid hormone signaling, reproductive biology (including sperm motility, acrosome function, and ovarian granulosa cell activity), autophagy regulation, and cholesterol metabolism. This rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of unconjugated antiserum and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human and mouse specimens. Polyclonal preparations raised against PGRMC2 often recognize multiple epitopes spanning the cytochrome b5-like heme/steroid-binding domain, which is useful in tissues where isoform expression or post-translational modification patterns vary between cell types. Investigators studying progesterone-driven signaling pathways, male and female fertility models, and steroidogenesis use this reagent to assess PGRMC2 abundance in tissue lysates and fixed sections. The unconjugated format supports flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies and custom detection chemistries, and the 100 µl working volume accommodates multiple replicate experiments across blots or slides.