Anti-PGRMC2 Antibody

Antibodies.com offers a rabbit polyclonal antibody raised against Progesterone Receptor Membrane Component 2 (PGRMC2), a membrane-associated heme/steroid-binding protein implicated in progesterone responses, cytochrome P450 regulation, and control of cell survival in reproductive, hepatic, and neural tissues.

This unconjugated reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide, with an approximate pH of 7.2. Each vial contains 100 µL of antibody and is shipped refrigerated for research use only.

Validated applications include Western Blot (WB) and Immunocytochemistry (ICC). The antibody was raised in rabbit and shows reactivity across human, mouse, and rat samples, supporting comparative studies of PGRMC2 expression in cell culture and tissue lysates from these species.

PGRMC2 contains a cytochrome b5-like domain that coordinates heme and binds progesterone-related steroids. Researchers apply this reagent to study membrane-initiated steroid signaling, endoplasmic reticulum-associated progesterone responses, and PGRMC2 involvement in ovarian follicle survival, hepatic lipid metabolism, and neuronal protection assays.

Storage recommendation: keep refrigerated and aliquot to avoid repeated freeze-thaw cycles. The polyclonal format allows recognition of multiple epitopes on the target, which is helpful when probing endogenous PGRMC2 in transfected or primary cell models.