Anti-PGRMC1 Antibody

PGRMC1 (Progesterone Receptor Membrane Component 1) is a heme-binding membrane protein concentrated in the endoplasmic reticulum, with additional localization to the plasma membrane and within cytoplasmic vesicles.

• Format: unconjugated rabbit polyclonal, 100 µl aliquot
• Applications: Western blot, immunohistochemistry
• Reactivity: human, mouse, rat
• Host species: rabbit; clonality: polyclonal; conjugate: unconjugated

The reagent supports investigation of progesterone signaling, heme metabolism, autophagy regulation, and PGRMC1 function in steroid-responsive tissues including liver, uterus, kidney, and selected neuronal populations. Because the polyclonal format recognizes multiple epitopes, it generates robust signal in whole-cell lysates, membrane-enriched fractions, frozen cryosections, and formalin-fixed paraffin-embedded specimens. Aliquoting on receipt and storage at -20 °C preserves activity through repeated freeze-thaw cycles. Each lot produced by Antibodies.com is validated under controlled conditions to keep PGRMC1 localization studies reproducible across cell and tissue models in reproductive biology, neuroscience, and oncology research.