Anti-PGF Antibody

Placental Growth Factor (PGF), a vascular endothelial growth factor family member implicated in pathological angiogenesis and placental vascular development, is the target of this Rabbit polyclonal antibody from Antibodies.com. The unconjugated reagent is supplied in a 100 µl volume and is validated for Western Blot and Immunohistochemistry workflows, with cross-reactivity confirmed in human and rat samples.

Shipped as a liquid aliquot, the antibody can be paired with a custom secondary reporter (HRP, biotin, fluorophore) to match diverse detection chemistries, from chemiluminescent Western Blot membranes to chromogenic or fluorescent staining of formalin-fixed, paraffin-embedded tissue sections. Long-term storage at -20 °C is recommended, with aliquoting on first use to limit freeze-thaw cycles and preserve titre. Intended for research use only.

PGF signals primarily through VEGFR1 (Flt-1) and is widely studied as a circulating biomarker in preeclampsia, ischemic cardiovascular disease, and tumor neovascularization. Investigators use PGF expression patterns to stratify disease severity, monitor response to anti-angiogenic therapy, and explore the molecular switch between healthy and pathological vessel growth. The polyclonal format increases the likelihood of recognizing multiple epitopes on the PGF dimer and its isoforms, improving detection in tissues where antigen accessibility varies with fixation and processing.