Anti-PFN1 Antibody

This polyclonal reagent from Antibodies.com targets Profilin-1 (PFN1), an actin-monomer-binding protein that orchestrates cytoskeletal remodeling, membrane trafficking, and small-GTPase signaling in eukaryotic cells. Raised in rabbit and supplied as a 200 µl aliquot of IgG, the antibody is validated for Western blot detection of the human target and is provided in an unconjugated format that pairs with the secondary detection system of the researcher's choice.

Independent studies have linked PFN1 to cytoskeletal dysregulation in neurodegenerative disease, including familial ALS-linked variants that perturb actin dynamics in motor neurons, making a well-characterized anti-PFN1 reagent useful for work on neuronal maintenance, cell migration, endocytosis, and actin-driven signaling cascades. Related research areas include cytoskeleton biology, neurobiology, vascular biology, and Rho-family GTPase signaling.

Storage: store at -20°C in working aliquots to limit freeze-thaw cycles and preserve antibody activity. Applications: WB (Western blot). Host: Rabbit. Clonality: Polyclonal. Isotype: IgG. Conjugate: Unconjugated. Reactivity: Human. Target: PFN1.