Anti-PFN1 Antibody

Profilin-1 (PFN1), an actin-binding protein that regulates cytoskeletal dynamics and cell motility, is the target of this polyclonal reagent raised in rabbit. The unconjugated IgG antibody recognizes the human Profilin-1 sequence and is validated for Western blot applications, enabling detection of endogenous PFN1 in cell lysates and tissue homogenates by immunoblotting.

Profilin-1 is studied extensively in actin remodeling, neuronal cytoskeleton organization, and the pathology of neurodegenerative disease, since mutations in PFN1 have been linked to familial amyotrophic lateral sclerosis (ALS). Each vial from Antibodies.com provides 100 µl of ready-to-use antibody, supplied at a working dilution suitable for standard WB protocols.

Aliquots should be refrigerated at 4°C for short-term storage or frozen at -20°C for longer-term stability, with repeated freeze-thaw cycles avoided to preserve binding activity. The polyclonal host response targets multiple epitopes across PFN1, supporting robust signal on membranes probed for the approximately 15 kDa Profilin-1 band.