Anti-PFN1 Antibody

Profilin-1 (PFN1) is a small, ~15 kDa actin-monomer binding protein that catalyzes the exchange of ADP for ATP on G-actin and plays a central role in cytoskeletal remodeling, membrane protrusion, and intracellular trafficking. This rabbit polyclonal primary antibody from Antibodies.com is raised against PFN1 and is supplied as an unconjugated 100 µl liquid aliquot suitable for western blot (WB) and immunohistochemistry (IHC) workflows. It has been validated to detect the human, mouse, and rat Profilin-1 orthologs, supporting comparative studies in cell-line and tissue-based models. Researchers use it to probe PFN1 expression in contexts ranging from actin dynamics and cell migration to investigations of PFN1 mutations linked to familial amyotrophic lateral sclerosis (ALS), as well as cancer, neuronal, and vascular biology research. The polyclonal format increases the likelihood of recognizing multiple epitopes on Profilin-1, which is helpful when studying post-translational modifications or mutant variants. Store refrigerated and avoid repeated freeze-thaw cycles to preserve activity; for long-term use, aliquot and keep frozen.