Anti-PEX7 Antibody

Raised in rabbit against peroxisomal biogenesis factor 7, this polyclonal primary antibody targets the cytosolic PTS2 receptor that recognizes peroxisomal targeting signal type 2 cargo and mediates its import across the peroxisomal membrane. Mutations in the PEX7 gene are linked to rhizomelic chondrodysplasia punctata type 1, a peroxisome biogenesis disorder characterized by impaired ether phospholipid biosynthesis and defective very-long-chain fatty acid metabolism, so a specific PEX7 reagent is broadly useful to researchers studying Zellweger spectrum disorders and peroxisomal protein trafficking.

Distributed by Antibodies.com, the reagent is supplied as a 100 µl aliquot of unconjugated rabbit polyclonal serum that has been validated for Western blot and immunohistochemistry on human and mouse samples. Working dilutions should be optimized empirically for each detection system; the antibody is compatible with standard chemiluminescent Western blot workflows and with chromogenic or fluorescence IHC on formalin-fixed paraffin-embedded tissue sections. The unconjugated format allows researchers to pair the antibody with their preferred secondary reporter, including anti-rabbit HRP, biotin, or fluorophore conjugates.

PEX7 is broadly expressed across tissues with peroxisomal activity, including liver, kidney, and brain, where it participates in the post-translational import of matrix enzymes such as alkyl-dihydroxyacetonephosphate synthase. Each vial should be aliquoted to limit freeze-thaw cycles and stored refrigerated between uses to preserve activity. For research use only; not intended for diagnostic or therapeutic applications.