Anti-PEX16 Antibody

This polyclonal antibody targets PEX16, a peroxisomal biogenesis factor that anchors peroxisomal membrane proteins and supports organelle growth and division. PEX16 mediates the insertion of integral membrane proteins into the peroxisomal membrane and contributes to the maintenance of functional peroxisomes, making it a reference marker for studies of organelle biogenesis, protein trafficking, and metabolic compartmentalization. Loss-of-function mutations in the PEX16 gene are linked to Zellweger spectrum disorders, including Zellweger syndrome and neonatal adrenoleukodystrophy, so the antibody is widely applied in cell biology and disease research to characterize peroxisome content and biogenesis defects.

Raised in rabbit and supplied at 50 µl as an unconjugated IgG preparation, this reagent from Antibodies.com is validated for western blot analysis and cross-reacts with both human and mouse samples, supporting comparative studies across model systems and patient-derived material. Researchers commonly use it to confirm PEX16 expression in patient fibroblasts, to monitor peroxisome reconstitution in knockout rescue experiments, and to probe peroxisomal dynamics in hepatocytes, neurons, and heterologous expression models. The unconjugated format allows flexible pairing with custom secondary labels and supports both chemiluminescent and fluorescence immunoblotting workflows.