Anti-PER3 Antibody

This rabbit polyclonal antibody specifically recognizes human Period Circadian Regulator 3 (PER3), a core component of the mammalian circadian clock machinery that regulates 24-hour rhythms in transcription and behavior. Produced and validated by Antibodies.com, the reagent is raised in rabbit and supplied as an unconjugated, affinity-purified preparation in 100 µl vial format, intended for immunodetection workflows in circadian biology and sleep research laboratories.

The antibody has been validated for Western blot (WB) and immunohistochemistry (IHC), enabling detection of endogenous PER3 protein in tissue sections and whole-cell lysates. It shows reactivity with human, mouse, and rat samples, supporting comparative studies of PER3 expression across rodent models and human clinical specimens. For optimal results, store aliquots refrigerated at 4°C, avoid repeated freeze-thaw cycles, and protect from light to preserve antibody activity over the product's shelf life.

Researchers commonly apply this reagent to investigate clock gene regulation, phase-shift responses, and the contribution of PER3 polymorphisms to delayed sleep phase disorder, seasonal affective disorder, and metabolic phenotypes. The unconjugated format gives users full flexibility to choose HRP, biotin, or fluorophore conjugates tailored to their assay platform.