Anti-PEPD Antibody

Polyclonal antiserum raised in rabbit against human peptidase D (PEPD), a cytosolic manganese-dependent metallopeptidase that hydrolyzes imidodipeptides bearing a C-terminal proline or hydroxyproline residue.

Because PEPD liberates free proline for de novo collagen biosynthesis and salvages hydroxyproline from degraded matrix fragments, the enzyme sits at a key regulatory point in extracellular matrix turnover, wound healing, and connective tissue homeostasis.

Biallelic loss-of-function variants in the PEPD gene cause prolidase deficiency, a rare autosomal recessive disorder characterized by chronic skin ulceration, facial dysmorphism, recurrent infections, and intellectual disability, so robust immunological detection of the protein is valuable for studies of inherited metabolic disease and collagen recycling.

This unconjugated rabbit polyclonal reagent from Antibodies.com is provided as a 100 µl liquid aliquot and is validated for western blot and immunohistochemistry applications on human samples, enabling confirmation of band identity after immunoprecipitation and localization of the enzyme within fixed tissue sections.