Anti-PEK / PERK (Ab-981) Antibody

This rabbit polyclonal reagent from Antibodies.com recognizes the PEK/PERK kinase (also known as EIF2AK3), an endoplasmic reticulum-resident enzyme that drives the translational control arm of the unfolded protein response. The antibody supports studies of ER stress biology, secretory pathway dysfunction, and the integrated stress response in cancer, neurodegeneration, and metabolic disease research.

Validated for western blot and immunohistochemistry on human samples, the antibody produces a band at the expected molecular weight in immunoblots and generates cytoplasmic staining consistent with the known ER localization of PERK in fixed tissue sections. The unconjugated format allows researchers to pair the reagent with HRP-, biotin-, or fluorophore-conjugated secondaries for chromogenic IHC, immunofluorescence, or chemiluminescent western blot detection.

Supplied as 100 µL of polyclonal antiserum, this reagent offers broader epitope coverage than monoclonal alternatives and tolerates multiple rounds of probing across varied sample preparations. Refrigerate for short-term use, aliquot and freeze in working volumes for long-term storage, and limit freeze-thaw cycles to preserve binding activity.