Anti-PECAM1 Antibody

This unconjugated Rabbit polyclonal reagent from Antibodies.com targets PECAM1 (CD31), a 130 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. PECAM1 is expressed constitutively on endothelial cells at tight junctions, on platelets, and on subsets of leukocytes including monocytes and neutrophils, where it mediates leukocyte transendothelial migration, integrin activation, and homophilic cell-cell adhesion.

Validated for Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows, this primary antibody reacts with Human, Mouse, and Rat samples, supporting comparative vascular biology, inflammation, and angiogenesis studies across standard preclinical model organisms. Each vial is supplied at 100 µL of IgG polyclonal serum, unconjugated for flexible secondary labeling with fluorophore- or enzyme-conjugated reporters of the user's choice.

Researchers studying tumor neovascularization, vascular permeability, endothelial barrier function, and cardiovascular disease routinely use anti-PECAM1 antibodies to identify and quantify endothelial cells within tissue sections and to immunoprecipitate PECAM1 complexes from cell lysates. Aliquot the polyclonal stock upon receipt to minimize freeze-thaw cycles, and protect from light if reconstituted with a chromogenic or fluorescent conjugate downstream.