Anti-PEBP1 Antibody

PEBP1 (phosphatidylethanolamine-binding protein 1), also known as RKIP, is a broadly expressed signaling modulator that regulates the Raf/MEK/ERK cascade and has been linked to tumor suppression, metastatic spread, neural differentiation, and the generation of a neurotoxic fragment implicated in Alzheimer's pathology. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against PEBP1 and validated for Western blot and immunohistochemistry on human and mouse specimens. The unconjugated format permits flexible pairing with HRP, Alexa Fluor, or biotin secondary detection chemistries chosen by the user.

Supplied as 100 µL of polyclonal antiserum, the reagent yields a specific band near 21 kDa on Western blot and provides robust cytoplasmic and nuclear staining on formalin-fixed paraffin-embedded tissue sections. Recommended storage at 4°C preserves activity across routine immunodetection workflows, and aliquoting upon receipt limits freeze-thaw cycles to help sustain titer over extended use. Investigators profiling RKIP loss in prostate, colorectal, or breast tumor models, or tracking cleaved PEBP1 species in neurodegeneration studies, can deploy this reagent for expression profiling, subcellular localization, and validation of pathway disruption phenotypes.