Anti-PDZK1 Antibody

PDZK1 (PDZ domain-containing protein 1) is a scaffolding adapter that organizes multi-protein complexes at the apical membrane of polarized epithelial cells. The Antibodies.com rabbit polyclonal anti-PDZK1 reagent recognizes an epitope on this scaffold protein and is validated for Western blot and immunohistochemistry workflows on Human, Mouse, and Rat samples.

Raised in rabbits, the polyclonal antiserum is supplied as an unconjugated IgG fraction in a 100 µl vial. The unconjugated format allows direct conjugation to fluorophores, biotin, or enzymes depending on the assay design, supporting immunofluorescence, immunoprecipitation, and co-localization studies alongside the validated WB and IHC uses. Polyclonal reactivity broadens epitope coverage across PDZK1 isoforms and splice variants.

PDZK1 coordinates several membrane transporters, including NHE3 in renal proximal tubules and contributes to hepatic and enterocyte lipid handling through interactions with SR-B1 and ABCG5/ABCG8. Researchers applying this antibody to kidney, liver, or intestinal tissue sections can therefore probe how PDZK1 expression shifts in transport physiology, metabolic disease models, or cancer contexts where the scaffold is dysregulated. For best stability, aliquot upon receipt and store frozen to limit freeze-thaw loss of titer.