Anti-PDS5A Antibody

PDS5A (Sister Chromatid Cohesion Protein PDS5 Homolog A) is a critical regulator of the cohesin complex, controlling sister chromatid cohesion during mitosis and facilitating DNA double-strand break repair through homologous recombination pathways. This rabbit polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated 100 µl vial, raised against the human PDS5A target and validated for Western blot detection.

Researchers studying cell cycle progression, chromosome segregation fidelity, and cancer biology—particularly contexts where PDS5A dysfunction has been linked to Cornelia de Lange syndrome-like phenotypes—can use this antibody to analyze protein expression in human cell lysates. The reagent is reactive with human samples and should be stored frozen in working aliquots to preserve functional activity through repeated use, with freeze-thaw cycles minimized to maintain binding affinity. For research use only, this antibody supports investigations into cohesinopathy mechanisms, replication fork stability, and the contribution of PDS5A to genomic integrity maintenance.