Anti-PDK1 (Ab-241) Antibody

This rabbit polyclonal reagent from Antibodies.com recognizes 3-phosphoinositide-dependent protein kinase 1 (PDPK1), the AGC-family master kinase that phosphorylates Akt/PKB at Thr308 and couples PI3K lipid signaling to cell growth, survival, and glucose homeostasis. Supplied as 100 µl of unconjugated antiserum, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples. Investigators apply it to map PDPK1 expression and activity in insulin signaling studies, tumor biology research, and models of cardiac hypertrophy, where altered PDPK1 function is implicated in disease progression. The polyclonal format yields strong signal in lysate-based readouts and supports localization studies in fixed tissue sections and cultured cell lines, making it well suited for pathway-focused characterization alongside downstream Akt substrate analysis.